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WO2016187508A2 Shared neoantigens Google Patents

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This week in HST - September 7, 2018 - Volume 20, Number 2 | Harvard-MIT Health Sciences and Technolo

and a sense of human solidarity and shared responsibility for our common future" (UNESCO, 2015). ... The Company’s initial goal is to identify and deploy neoantigens for novel treatments for lung and gastric cancer. In addition to neoantigen ...

TILT Biotherapeuti

About TILT Biotherapeutics Ltd is the leading company globally working in the area of enabling tumor T-cell therapy and checkpoint inhibitors with oncolytic viruses. TILT Biotherapeutics is developing a new treatment for cancer using oncolytic immunotherapy.

Progress in Adaptive Immunotherapy for Cancer in Companion Animals: Success on the Path to a Cu

It has been suggested that the high rate of mutation seen in melanoma produces neoantigens which can be successfully targeted by the TILs that mediate tumor ...

Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming | Cancer Resear

with increases in the titer of antibodies against the shared tumor antigen NY-ESO1 (). ... Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming María E. , , , ...

Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1 | Journal for ImmunoTherapy of Cancer | Full Te

epitope prediction algorithms allow for the systematic screening of cancer patients for reactivity towards shared driver mutations, ... D.M.P. has ownership interest (including patents) in BMS, MedImmune/AstraZeneca, and Potenza, and is a consultant ...

Recent advances in T-cell engineering for use in... | F1000Resear

Adoptive T-cell therapies have shown exceptional promise in the treatment of cancer, especially B-cell malignancies. Two distinct strategies have been used to redirect the activity of ex vivo engineered T cells. In one case, the well-known ability of the T-cell receptor ...

(PDF) Effective screening of T cells recognizing neoantigens and construction of T-cell receptor-engineered T cel

Effective screening of T cells recognizing neoantigens and construction of T-cell receptor-engineered T cells Article (PDF Available) ... specifi c antigens, neoantigens and shared antigens, can activate or induce antigen-speci ...

Genomic analysis of 63,220 tumors reveals insights into tumor uniqueness and targeted cancer immunotherapy strategies | Genome Medicine | Full Te

Genomic analysis of 63,220 tumors reveals insights into tumor uniqueness and targeted cancer immunotherapy strategies Ryan J. Hartmaier 1, Jehad Charo 2, David Fabrizio 1, ...

Recent advances in endometrial cancer: a review... | F1000Resear

MSI and polymerase-ε (POLE) lead to neoantigens, fragments of proteins expressed by tumor cells that may sensitize the immune system 52. ...

Genomic analysis of 63,220 tumors reveals insights into tumor uniqueness and targeted cancer immunotherapy strategies | SpringerLi

Genomic analysis of 63,220 tumors reveals insights into tumor uniqueness and targeted cancer immunotherapy strategies Authors Authors and affiliations Ryan J. Hartmaier Jehad Charo David Fabrizio Michael E. Goldberg ...

WO2016187508A2 - Shared neoantigens - Google Paten

Disclosed herein in one aspect is a pharmaceutical composition comprising a plurality of neoantigenic peptides and a pharmaceutically acceptable carrier, each neoantigenic peptide comprising a tumor-specific neoepitope capable of binding to an HLA protein in a ...

DNA Vaccine–Induced Long-Lasting Cytotoxic T Cells Targeting Conserved Elements of Human Immunodeficiency Virus Gag Are Boosted Upon DNA or .

†Current affiliations: Dr. Yanhui Cai, IV-1 Immunopathogenesis Laboratory, The Wistar Institute, Philadelphia, PA 19104; Dr. Eric G. Ramirez-Salazar, Consejo Nacional de Ciencia y Tecnología (CONACYT)-Laboratorio de Genómica del Metabolismo Óseo, Instituto ...

Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity: Immuni

The shared usage of MyD88 by IL-1R family members raises the issue of the mechanism(s) responsible for generation of response specificity. ...

This week in HST - September 21, 2018 - Volume 20, Number 4 | Harvard-MIT Health Sciences and Technolo

any side/personal projects could also be considered. Patents are encouraged but not required. ... Gritstone is leveraging its unique antigen discovery platform to define targets for shared antigen immunotherapies, which would provide an opportunity to ...

Therapeutic cancer vaccin

Vaccines for nonviral cancers have targeted shared antigens. Vaccines against nonviral cancers have largely utilized target molecules, such as differentiation antigens, cancer testis (CT) ...

tgs.freshpatents.c

Methods for detection of respiratory diseases Disclosed are methods of identifying, predicting and treating subjects at risk for exacerbation or the presence of a respiratory dise

JCI - Therapeutic cancer vaccines - Journal of Clinical Investigati

Vaccines for nonviral cancers have targeted shared antigens. Vaccines against nonviral cancers have largely utilized target molecules, such as differentiation antigens, cancer testis (CT) antigens, or overexpressed antigens ...

Gene and Variant Annotation for Mendelian Disorders in the Era of Advanced Sequencing Technologies | Annual Review of Genomics and Human Geneti

Human-gibbon speciation time is derived from an estimated population size shared with the human-orangutan ancestor and the human-gibbon divergence ...

Dynamics of Tumor and Immune Responses during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer | Cancer Resear

We did not identify any shared TCR clones among the differentially expanded ones for all patients analyzed, ... summary, we have developed dynamic assays that capture the tumor-immune system equilibrium and assess immune editing of neoantigens during ...

Actively personalized vaccination trial for newly diagnosed glioblastoma | Natu

data will be shared (with identifying information removed) upon reasonable request. ... R. D. Neoantigens in cancer immunotherapy. Science 348, 69–74 (2015). ADS CAS Article Google Scholar 9. Yadav, M. et al. Predicting immunogenic tumour Nature ...

WO2016187508A3 - Shared neoantigens - Google Paten

PCT/US2016/033452 2015-05-20 2016-05-20 Shared neoantigens WO2016187508A2 (en) Priority Applications (4) Application Number Priority Date Filing Date Title US201562179877P true ...